GRAPH-THEORETIC APPROACH TO METABOLIC PATHWAYS

被引：0
|
作者：
GOLDSTEIN, BN [1 ]
SELIVANOV, VA [1 ]
机构：
[1] ACAD SCI USSR, INST BIOL PHYS, PUSHCHINO, USSR
来源：
BIOMEDICA BIOCHIMICA ACTA | 1990年 / 49卷 / 8-9期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A graph-theoretic approach is shown to be applicable within the framework of the metabolic control analysis. Kinetic differential equations linearized near a steady state are presented as kinetic graphs (schemes), their structure being correlated with kinetic properties of corresponding metabolic networks. The global properties may be expressed in terms of the local properties for steady states of metabolic systems. Instability, bistability, and concentrational oscillations are shown to be induced by specific graph fragments. The approach is illustrated by an example of systems showing the oscillatory kinetic behaviour.
引用
收藏
页码：645 / 650
页数：6
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