A BASE-PAIR BETWEEN TRANSFER-RNA AND 23S RIBOSOMAL-RNA IN THE PEPTIDYL TRANSFERASE CENTER OF THE RIBOSOME

被引：215
|
作者：
SAMAHA, RR [1 ]
GREEN, R [1 ]
NOLLER, HF [1 ]
机构：
[1] UNIV CALIF SANTA CRUZ, SINSHEIMER LABS, CTR MOLEC BIOL RNA, SANTA CRUZ, CA 95064 USA
来源：
NATURE | 1995年 / 377卷 / 6547期
关键词：
D O I：
10.1038/377309a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A Watson-Crick G-C pair between G2252 in a conserved hairpin loop of 235 rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.
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页码：309 / 314
页数：6
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