NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF THE CANINE ADENOVIRUS TYPE-1 PROTEINASE

被引：3
|
作者：
CAI, FX [1 ]
WEBER, JM [1 ]
机构：
[1] UNIV SHERBROOKE,FAC MED,DEPT MICROBIOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA
来源：
VIRUS GENES | 1992年 / 6卷 / 03期
关键词：
CANINE ADENOVIRUS TYPE-1; PROTEINASE;
D O I：
10.1007/BF01702569
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The DNA sequence of an open reading frame (ORF) corresponding to the canine adenovirus type 1 (Can1) proteinase gene was determined. A total of 1171 base pairs were sequenced from the downstream end of the HindIII-A Can1 genomic fragment, including adjacent regions corresponding to the carboxy-terminal portions of the hexon and the DNA-binding proteins. The predicted Can1 proteinase consists of 206 residues (23,325 D) of which 68% are identical and 83% are similar to the sequence of the human Ad2 proteinase. Alignment with the Ad2 proteinase identified a number of conserved residues that could form part of the catalytic triad of the enzyme.
引用
收藏
页码：307 / 312
页数：6
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