5-FLUOROURACIL-METHOTREXATE SYNERGY - ENHANCEMENT OF 5-FLUORODEOXYURIDYLATE BINDING TO THYMIDYLATE SYNTHASE BY DIHYDROPTEROYLPOLYGLUTAMATES

被引：74

作者：

FERNANDES, DJ ^{[1
]}

BERTINO, JR ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT MED,NEW HAVEN,CT 06510

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1980年 / 77卷 / 10期

关键词：

D O I：

10.1073/pnas.77.10.5663

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：5663 / 5667

页数：5

共 50 条

[1] BINDING OF 5-FLUORODEOXYURIDYLATE TO THYMIDYLATE SYNTHASE IN HUMAN-COLON ADENOCARCINOMA XENOGRAFTS
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[2] QUINAZOLINE FOLATE ANALOGS INHIBIT THE CATALYTIC ACTIVITY OF THYMIDYLATE SYNTHASE BUT ALLOW BINDING OF 5-FLUORODEOXYURIDYLATE
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[3] SPECTROPHOTOMETRIC TITRATION OF THYMIDYLATE SYNTHETASE WITH 5-FLUORODEOXYURIDYLATE
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[8] DETERMINANTS OF SENSITIVITY TO 5-FLUOROURACIL (5-FU) - NEW ULTRASENSITIVE ASSAYS FOR 5-FLUORODEOXYURIDYLATE (FDUMP), DEOXYURIDYLATE (DUMP), AND THYMIDYLATE SYNTHETASE (TS)
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[9] ACTIVATION AND PROTECTION FROM 5-FLUORODEOXYURIDYLATE INACTIVATION OF MAMMALIAN THYMIDYLATE SYNTHETASE BY PYRIDOXAL 5'-PHOSPHATE
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[10] RAPID KINETIC-ANALYSIS OF 5-FLUORODEOXYURIDYLATE BINDING IN A NATURALLY-OCCURRING MUTANT FORM OF HUMAN THYMIDYLATE SYNTHASE - COMPARISON TO THE WILD-TYPE ENZYME
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