Protective Effect of Dichloromethan Extract of Cassia alata (Linn.) Leaves on Complete Freund's Adjuvant-Induced Inflammation in Rats

To evaluate the anti-inflammatory and protective effect of Cassia alata (Linn.) leaves is the objective of this study. The anti-inflammatory and protective effect of dichloromethan extract of Cassia alata (Linn.) leaves (CF-AECal) has been studied according to Freund's adjuvant-induced arthritic rat models. CF-AECal 50 mg/Kg, 100 mg/Kg and dexamethasone 1 mg/Kg were the doses of drugs receipt by rats. CF-AECal 100 mg/Kg showed a substantial anti-inflammatory and protective effect. CF-AECal 50 and 100 mg/Kg produced antioxidant effects in Freund's adjuvant-induced paw edema. Indeed, antioxidant enzymes are maintained more or less that their normal rate. These antioxidant effects protect the liver, the kidney and the spleen highly (p< 0.001). CF-AECal 50 and 100 mg/Kg lead to a significant decline in the rate of serum enzymes (AST, PAL and CREA) and a decrease of the serum concentration of total bilirubin and protein compared to animals of the control group ignited. At the doses of the extract used, the leukocyte infiltration is reduced in the cutaneous cloths of the paws of rats. In conclusionCassia alata leaves extractshows anti-inflammatory and protective effects