METHYLATION-DEPENDENT AND METHYLATION-INDEPENDENT DNA-BINDING OF NUCLEAR FACTOR EF-C

被引：11
|
作者：
GARCIA, AD [1 ]
OSTAPCHUK, P [1 ]
HEARING, P [1 ]
机构：
[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT MICROBIOL,STONY BROOK,NY 11794
来源：
VIROLOGY | 1991年 / 182卷 / 02期
关键词：
D O I：
10.1016/0042-6822(91)90629-P
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Nuclear factor EF-C binds to important functional sites in the hepatitis B virus and polyomavirus enhancer regions. In this paper, we have characterized new and divergent EF-C binding sites in several viral regulatory regions. We also have demonstrated that EF-C binds to certain DNA sites only when CpG dinucleotide base pairs are methylated (m5C). EF-C binds to other sites in a methylation-independent manner. Based on similar binding properties and identical binding sites, it is very likely that EF-C corresponds to the nuclear protein MDBP previously identified by virtue of binding to methylated DNA. © 1991.
引用
收藏
页码：857 / 860
页数：4
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