VERSATILE SYNTHESIS OF 6-ALKYL-1H-PRYAZOLO[3,4-D]PYRIMIDIN-4[5H]-ONES AND 6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4[5H]-ONES

被引：0
|
作者：
REDDY, KH [1 ]
REDDY, AP [1 ]
VEERANAGAIAH, V [1 ]
机构：
[1] OSMANIA UNIV,NIZAM COLL,DEPT CHEM,HYDERABAD 500001,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1992年 / 31卷 / 03期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Condensation of 5-amino-1H-pyrazole-4-carboxamide (1a) with various aromatic aldehydes furnishes 6-substituted-1H-pyrazole[3,4-d]pyrimidin-4(5H)-ones (4a-f) via the intermediates 5-(N-arylideneamino)pyrazole-4-carboxamides (3a-f). Compounds 4a-f have also been synthesised by the reaction of 1a with aromatic carboxylic acids in polyphosphoric acid (PPA) or polyphosphate ester (PPE). Similar treatment of 5-amino-1-methyl/phenyl-1H-pyrazole-4-carboxamide (1b and 1c) with aromatic aldehydes and aromatic carboxylic acids gives exclusively 6-substituted-1-methyl/phenyl-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-ones (4g-n). The title compounds have also been synthesised by the reaction of 1 with arylideneanilines.
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页码：163 / 166
页数：4
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