SITES OF B-CELL ACTIVATION INVIVO

被引：59
|
作者：
KELSOE, G
ZHENG, B
机构：
[1] University of Maryland School of Medicine, Baltimore
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 03期
关键词：
D O I：
10.1016/0952-7915(93)90062-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.
引用
收藏
页码：418 / 422
页数：5
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