FMOC-AMINO ACID CHLORIDES-KOBT IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：0
|
作者：
SIVANANDAIAH, KM
BABU, VVS
GANGADHAR, BP
机构：
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1994年 / 33卷 / 07期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fmoc-amino acid chlorides can be used along with KOBt instead of the routinely employed 1:1 mixture of base (TEA or DIEA) and catalyst (HOBt or Piv) in solid phase peptide synthesis. No additional base is required. Coupling is fast and racemization free. Thus, the opioid peptide, beta-casomorphin (Tyr-Pro-Phe-Pro-Gly) and the laminin fragment, Tyr-Ile-Gly-Ser-Arg-NH2 have been obtained in good yields as well as purity.
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页码：620 / 623
页数：4
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