PHOSPHINIC ACID ANALOGS OF GAMMA-AMINOBUTYRIC-ACID (GABA) - SYNTHESIS OF A NEW RADIOLIGAND

被引：8

作者：

HALL, RG

KANE, PD

BITTIGER, H

FROESTL, W

机构：

[1] CIBA GEIGY PLC,CENT RES LABS,MACCLESFIELD SK10 2NX,CHESHIRE,ENGLAND

[2] CIBA GEIGY PHARMACEUT CORP,HORSHAM RH12 4AB,W SUSSEX,ENGLAND

[3] CIBA GEIGY AG,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1995年 / 36卷 / 02期

关键词：

TRITIUM; GAMMA-AMINOPHOSPHINIC ACIDS; GABA-B; SYNTHESIS;

D O I：

10.1002/jlcr.2580360205

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a new radioligand, which binds with high selectivity and affinity (K-D=7.4 nM) to the GABA-B receptor, is described. A Wittig-Horner approach was employed to prepare an unsaturated protected intermediate (($) under bar 6), suitable for tritiation and deprotection.

引用

页码：129 / 135

页数：7

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