CHOLESTATIC PRURITUS - PATHOPHYSIOLOGY AND THERAPY WITH SPECIAL CONCERN ON ITS TREATMENT WITH 5-HYDROXYTRYPTAMINE SUBTYPE-3 RECEPTOR ANTAGONISTS

被引：0
|
作者：
SCHWORER, H
RAMADORI, G
机构：
来源：
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 1995年 / 33卷 / 05期
关键词：
CHOLESTIS; LIVER; PRURITUS; ITCH; NOCICEPTION; 5-HYDROXYTRYPTAMINE; SEROTONIN; 5-HT3 RECEPTOR ANTAGONIST; ONDANSETRON; TROPISETRON;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Our current knowledge about the pathophysiology of pruritus (itch) is summarized. Special concern is given to the hypotheses to explain itch due to cholestatic liver diseases (bile acids, generation of hepatic and intestinal pruritogens, endogenous opioids). Drugs used for the treatment of cholestatic itch are discussed in detail. On the basis of successful treatment of cholestatic itch with 5-hydroxytryptamine (serotonin) subtype-3 receptor antagonists the role of serotonin in nociception is discussed.
引用
收藏
页码：265 / 274
页数：10
相关论文
共 50 条
  • [41] Palonosetron versus first-generation 5-hydroxytryptamine type 3 receptor antagonists for emesis prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation
    Chou, Cheng-Wei
    Chen, Yeh-Ku
    Yu, Yuan-Bin
    Chang, Kuang-Hsi
    Hwang, Wen-Li
    Teng, Chieh-Lin Jerry
    ANNALS OF HEMATOLOGY, 2014, 93 (07) : 1225 - 1232
  • [42] Palonosetron versus first-generation 5-hydroxytryptamine type 3 receptor antagonists for emesis prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation
    Cheng-Wei Chou
    Yeh-Ku Chen
    Yuan-Bin Yu
    Kuang-Hsi Chang
    Wen-Li Hwang
    Chieh-Lin Jerry Teng
    Annals of Hematology, 2014, 93 : 1225 - 1232
  • [43] 5-Hydroxytryptamine (5-HT) Cellular Sequestration during Chronic Exposure Delays 5-HT3 Receptor Resensitization due to Its Subsequent Release
    Hothersall, J. Daniel
    Alexander, Amy
    Samson, Andrew J.
    Moffat, Christopher
    Bollan, Karen A.
    Connolly, Christopher N.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (46) : 32020 - 32029
  • [44] The thyroid status of rats immunized with peptides derived from the extracellular regions of the types 3 and 4 melanocortin receptors and the 1B-subtype 5-hydroxytryptamine receptor
    Derkach, K. V.
    Moiseyuk, I. V.
    Shpakova, E. A.
    Shpakov, A. O.
    JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2015, 51 (04) : 279 - 287
  • [45] The thyroid status of rats immunized with peptides derived from the extracellular regions of the types 3 and 4 melanocortin receptors and the 1B-subtype 5-hydroxytryptamine receptor
    K. V. Derkach
    I. V. Moiseyuk
    E. A. Shpakova
    A. O. Shpakov
    Journal of Evolutionary Biochemistry and Physiology, 2015, 51 : 279 - 287
  • [46] Novel 5-hydroxytryptamine (5-HT3) receptor antagonists .3. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives
    Ohta, M
    Suzuki, T
    Furuya, T
    Kurihara, H
    Tokunaga, T
    Miyata, K
    Yanagisawa, I
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, 44 (09) : 1707 - 1716
  • [47] 5-Hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis - Can we safely reduce the dose of administered agents?
    Aapro, M
    Blower, P
    CANCER, 2005, 104 (01) : 1 - 13
  • [48] SELECTIVE 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTOR ANTAGONISM WITH ONDANSETRON AS TREATMENT FOR DIARRHEA-PREDOMINANT IRRITABLE-BOWEL-SYNDROME - A PILOT-STUDY
    STEADMAN, CJ
    TALLEY, NJ
    PHILLIPS, SF
    ZINSMEISTER, AR
    MAYO CLINIC PROCEEDINGS, 1992, 67 (08) : 732 - 738
  • [49] Symposium on morbidity of body fluid balance and its treatment - 3. Vasopressin receptor antagonists - 2) Diuretic therapy
    Orita, Y
    Nakahama, H
    INTERNAL MEDICINE, 1998, 37 (02) : 219 - 221
  • [50] Association between variants of 5-hydroxytryptamine receptor 3C (HTR3C) and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast cancer
    Pud, Dorit
    Har-Zahav, Gil
    Laitman, Yael
    Rubinek, Tami
    Yeheskel, Adva
    Ben-Ami, Sarah
    Kaufman, Bella
    Friedman, Eitan
    Symon, Zvi
    Wolf, Ido
    BREAST CANCER RESEARCH AND TREATMENT, 2014, 144 (01) : 123 - 131
12345