SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF 1-(2,4-DISUBSTITUTED PHENOXY)-3-[N1-(N4-ARYLPIPERAZINYL)]PROPANES AND 1-(4-CHLOROBENZOYL)-3-SUBSTITUTED-6-METHOXY-2-(4-[3-N1-(N4-PHENYLPIPERAZINYL)PROPOXY]PHENYL)INDOLES

被引：0

作者：

AGARWAL, SK ^{[1
]}

SAXENA, AK ^{[1
]}

JAIN, PC ^{[1
]}

ANAND, N ^{[1
]}

SRIMAL, RC ^{[1
]}

DHAWAN, BN ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV EYE DIS,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1991年 / 30卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-(Substituted phenoxy/thiophenoxy)-3-[N1-(N4-arylpiperazinyl)propanes (2-5), 1-(2-chloro-4-nitrophenoxy)-3-{N1-[N4-(2-methoxyphenyl)piperazinyl]}propane-2-ol (7) and 1-(4-chlorobenzoyl)-3-substituted-6-methoxy-2-{4-[3-N1-(N4-phenylpiperazinyl)propoxy]phenyl}indoles (8c-e) have been synthesized and evaluated for their CNS, CVS, antiinflammatory, diuretic and PCA activities. Compounds 2a and 3a show interesting tranquilizing activity. Hypotensive action is shown by 4 and 7, while 2e, 3a-b and 8c-e possess antiinflammatory activity.

引用

页码：413 / 416

页数：4

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