PRODUCTION OF ARACHIDONIC-ACID METABOLITES BY CAPRINE ALVEOLAR MACROPHAGES

被引：0
|
作者：
ENGLEN, MD
TAYLOR, SM
LAEGREID, WW
SILFLOW, RM
BANKS, KL
LEID, RW
机构：
[1] LIGAND PHARMACEUT,SAN DIEGO,CA 92121
[2] USDA ARS,PLUM ISL ANIM DIS CTR,NAA,GREENPORT,NY 11944
来源：
INFLAMMATION | 1990年 / 14卷 / 03期
关键词：
D O I：
10.1007/BF00915808
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The in vitro release of arachidonic acid (AA) metabolites from caprine alveolar macrophages (CAM) stimulated with the calcium ionophore A23187 or opsonized zymosan was examined. Leukotriene B4 [5(S),12(R)-6,14-cis-8,10-trans-dihydroxyeicosatetraenoic acid] was the major AA metabolite elicited with either agonist; smaller amounts of 12- and 5-mono-hydroxyeicosatetraenoic acid (HETE), and 12-hydroxyheptadecatrienoic acid (HHT) were also detected. Zymosan stimulation also caused the release of very small quantities of prostaglandins E2 and F2α, and thromboxane B2. Our report is the first to describe arachidonic acid metabolism in CAM. © 1990 Plenum Publishing Corporation.
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页码：239 / 245
页数：7
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