LIPID A BINDING AND DEFORMABILITY OF ADULT RED-BLOOD-CELLS

被引：0

作者：

POSCHL, JMB ^{[1
]}

GALANOS, C ^{[1
]}

LINDERKAMP, O ^{[1
]}

机构：

[1] MAX PLANCK INST IMMUNOBIOL,FREIBURG,GERMANY

来源：

CLINICAL HEMORHEOLOGY | 1993年 / 13卷 / 01期

关键词：

LIPID-A; RED BLOOD CELL DEFORMABILITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid A is responsible for the endotoxic activities. The effect of different lipid A concentrations and incubation times on red blood cell (RBC) deformation was studied by means of a rheoscope. Lipid A concentrations Of 10 and 100 mug/ml decreased RBC deformability by 41% and 46%, respectively, after 20 min of incubation. After 1 h, RBC deformability nearly reached preincubation values. Lipid A binding to RBC membranes (passive hemolysis test) was similar after 30 and 60 min incubation. This suggests that lipid A binding to RBC membrane does not change during this time, but that lipid A is inserted into the membrane, thereby improving RBC deformability.

引用

页码：45 / 48

页数：4

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