METAANALYSIS OF STIMULATION PROTOCOLS FOR INVITRO FERTILIZATION (IVF)

During january 1989, we analyzed 174 trials comparing various IVF ovarian stimulation protocols. Only 29 were randomized trials and after methodological discussion, we carried out two meta-analysis. The first one compares clomiphene citrate (CC) versus combination of clomiphene citrate and human follicle-stimulation hormone (CC + hMG). The second one compares large protocole (LP) versus short protocole (SP) using gonadotrophin releasing hormone agoniste. The rate of pregnancy by transfer were no satisticaly significant for the meta-analysis CC versus CC + hMG; but the power is weak. The rate of pregnancy by transfer were statisticaly significant for the meta-analysis LP versus SP but this later contents only three trials. This result must be proved including others randomized trials. The methodological study of all trials point out that protocols should be improved.