Finger clubbing is a striking clinical sign associated with a large variety of diseases and syndromes. Although clubbing is poorly understood, we hypothesise that there is a final common pathway in the pathogenesis of clubbing by which there is increased growth of connective tissue and augmented blood flow mediated or stimulated by cytokines, which are either over-produced or poorly eliminated.
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatopathol, Dept Pathol & Lab Med, Los Angeles, CA 90024 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatopathol, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA
Turegano, Mamina M.
Sperling, Leonard C.
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机构:
Uniformed Serv Univ Hlth Sci, Dept Dermatol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatopathol, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA
机构:
Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USAColorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA