INTERLEUKIN-10 INHIBITS ENDOTOXIN-INDUCED TISSUE FACTOR MESSENGER-RNA PRODUCTION BY HUMAN MONOCYTES

被引：50
|
作者：
RAMANI, M [1 ]
OLLIVIER, V [1 ]
KHECHAI, F [1 ]
VU, T [1 ]
TERNISIEN, C [1 ]
BRIDEY, F [1 ]
DEPROST, D [1 ]
机构：
[1] CHU XAVIER BICHAT,INSERM,U294,46 RUE HENRI HUCHARD,F-75877 PARIS 18,FRANCE
来源：
FEBS LETTERS | 1993年 / 334卷 / 01期
关键词：
TISSUE FACTOR; INTERLEUKIN-10; MONOCYTE; ENDOTOXIN;
D O I：
10.1016/0014-5793(93)81693-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in,septic shock, a condition still associated with a high mortality rate.
引用
收藏
页码：114 / 116
页数：3
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