PAF-ACETHER IN HUMAN SKIN

被引：0
|
作者：
DENIZOT, Y
MICHEL, L
BENVENISTE, J
MEYBECK, A
THOMAS, Y
DUBERTRET, L
机构：
[1] INSERM,U200,32 RUE CARNETS,F-92140 CLAMART,FRANCE
[2] INSERM,U312,F-92010 CRETEIL,FRANCE
[3] LVMH RECH,F-92704 COLOMBES,FRANCE
来源：
LIPIDS | 1991年 / 26卷 / 12期
关键词：
D O I：
10.1007/BF02536508
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Paf is a phospholipid mediator present in human skin which induces inflammatory events, such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions. It is tempting to speculate that paf may contribute to the development of various skin disorders with acute and chronic skin inflammation. Paf antagonists may help in bringing answers to this hypothesis and may offer new prospects for the treatment of cutaneous inflammatory diseases.
引用
收藏
页码：1093 / 1094
页数：2
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