CYCLOSPORINE FOR TREATMENT OF LIFE-THREATENING ALLOIMMUNIZATION

被引：9
|
作者：
TILLY, H
AZAGURY, M
BASTIT, D
LALLEMAND, A
PIGUET, H
机构：
[1] CTR REG TRANSFUS SANGUINE,BOIS GUILLAUME,FRANCE
[2] LABS SANDOZ,RUEIL MALMAISON,FRANCE
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 34卷 / 01期
关键词：
aplastic anemia; immunosuppression; transfusion;
D O I：
10.1002/ajh.2830340118
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe a 16‐year‐old girl with aplastic anemia who, 1 year after initial diagnosis, developed a refractory state to platelet transfusions due to alloimmunication and resulting in severe bleeding. Treatment with cyclosporin, initially prescribed as treatment of the bone marrow failure, resulted in prompt decrease in lymphocytotoxic antibodies, which paralleled a marked improvement in platelet recovery. To our knowledge, such a dramatic effect of cyclosporin on alloimmunization has not been previously reported and merits further attention. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码：75 / 76
页数：2
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