Ovarian stimulation with corifollitropin alfa

被引：0

作者：

Griesinger, G. ^{[1
,2
,3
]}

Diedrich, K. ^{[3
]}

Schultze-Mosgau, A. ^{[1
,2
,3
]}

机构：

[1] Univ Klinikum Schleswig Holstein, UKL Univ Kinderwunschzentrum Lubeck, Zentrum Gynakol Endokrinol & Reprodukt Med, Lubeck, Germany

[2] Ambulanzzentrum UK S H GmbH, Med Versorgungszentrum, Kiel, Germany

[3] Univ Klinikum Schleswig Holstein, Klin Frauenheilkunde & Geburtshilfe, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany

来源：

GYNAKOLOGISCHE ENDOKRINOLOGIE | 2011年 / 9卷 / 04期

关键词：

Ovulation induction; Fertilization in vitro; Corifollitropin alfa; Gonadotropin-releasing hormone; Antagonist;

D O I：

10.1007/s10304-011-0432-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Corifollitropin alfa is a new hybrid protein of human follicle-stimulating hormone (FSH) and the C-terminal peptide of the beta-subunit of human chorionic gonadotropin. Due to a slower absorption and a longer terminal half-life, corifollitropin alfa can induce multifollicular development in women undergoing controlled ovarian stimulation using gonadotropin-releasing hormone (GnRH) antagonist-assisted in vitro fertilization (IVF). In two large randomized, double-blind, phase III trials, a single subcutaneous injection of corifollitropin alfa was as effective as 7 daily injections of recombinant FSH in inducing multifoil icular development when used as part of a GnRH antagonist protocol. Non-inferiority in ongoing pregnancy rates and numbers of oocytes available for IVF has been established. In another large phase III trial, non-immunogenicity of corifollitropin alfa has been demonstrated.

引用

页码：223 / 228

页数：6

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