CHANGES OF PLATELET FUNCTIONS BY EXTRACELLULAR-SODIUM ION

被引：3
|
作者：
ISHIKAWA, Y
OGAWA, A
SASAKAWA, S
机构：
[1] The Japanese Red Cross Central Blood Center, Shibuya-ku, Tokyo, 150, 4-1-31, Hiroo
来源：
THROMBOSIS RESEARCH | 1991年 / 61卷 / 03期
关键词：
PLATELET; EXTRACELLULAR NA+; CYTOPLASMIC PH; NA+/H+ EXCHANGER; AGGREGATION; SEROTONIN RELEASE;
D O I：
10.1016/0049-3848(91)90110-I
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effects of extracellular Na+ on platelet responses were examined. Cytoplasmic pH decreased by stimulation with thrombin, TPA and AA in Na+-containing buffer as well as in Na+-free buffer. Thrombin-induced aggregation and serotonin release were higher in Na+-containing buffer, but TPA- and A23187-induced responses exhibited lower values. Thrombin-stimulated platelet in Na+-free buffer started to aggregate by the addition of NaCl. Inhibition of thrombin-induced aggregation by indomethacin was apparently weaker than that by removal of Na+. These results suggest that the changes of platelet responses by removal of Na+ is due to the effect of Na+ ion itself, not by the inhibition of Na+/H+ exchanger, and that Na+ affects on mechanisms other than arachidonic acid mobilization.
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页码：327 / 334
页数：8
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