DOSE-DEPENDENT EFFECTS OF ZINC SUPPLEMENTATION DURING CHELATION OF LEAD IN RATS

被引：12
|
作者：
FLORA, SJS
BHATTACHARYA, R
SACHAN, SRS
机构：
[1] Defence Research and Development Establishment, Division of Pharmacology and Toxicology, Gwalior, 474 002, Tansen Road
来源：
PHARMACOLOGY & TOXICOLOGY | 1994年 / 74卷 / 06期
关键词：
D O I：
10.1111/j.1600-0773.1994.tb01368.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dose-dependent effects of zinc supplementation in order to enhance the efficacy of calcium disodium EDTA in lead intoxicated rats was investigated in rats. The results suggest simultaneous supplementation of zinc at a lower concentration i.e. 10 mg/kg (orally, once during chelation treatment), 25 mg/kg zinc (Flora & Tandon 1990) potentiates the mobilization of lead from blood and soft tissues. However, at a higher dose level (50 mg/kg once orally) it has deleterious and much reduced ability to deplete tissue lead contents and restore altered lead sensitive biochemical variables.
引用
收藏
页码：330 / 333
页数：4
相关论文
共 50 条
  • [41] Differential metformin dose-dependent effects on cognition in rats: role of Akt
    Mostafa, Dalia K.
    Ismail, Cherine A.
    Ghareeb, Doaa A.
    PSYCHOPHARMACOLOGY, 2016, 233 (13) : 2513 - 2524
  • [42] Dose-dependent Effects of Cacao Polyphenol Intake on Lipid Metabolism in Rats
    Aono, Yuka
    Kaido, Takanobu
    Kita, Nagisa
    Sugiyama, Kaho
    Sumikawa, Maho
    Nakayama, Shizuka
    Fukushima, Yukiko
    PLANT FOODS FOR HUMAN NUTRITION, 2021, 76 (02) : 254 - 255
  • [43] The dose-dependent effects of phencyclidine on behaviour and immediate early genes in rats
    Bobanovic, MB
    Dursun, SM
    Robertson, HA
    BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 : U39 - U39
  • [44] Dose-dependent effects of lead induced gut injuries: An in vitro and in vivo study
    Yu, Leilei
    Yu, Yaqi
    Yin, Ruijie
    Duan, Hui
    Qu, Dingwu
    Tian, Fengwei
    Narbad, Arjan
    Chen, Wei
    Zhai, Qixiao
    CHEMOSPHERE, 2021, 266 (266)
  • [45] TESTOSTERONE AS APPETITIVE AND DISCRIMINATIVE STIMULUS IN RATS - SEX-DEPENDENT AND DOSE-DEPENDENT EFFECTS
    DEBEUN, R
    JANSEN, E
    SLANGEN, JL
    VANDEPOLL, NE
    PHYSIOLOGY & BEHAVIOR, 1992, 52 (04) : 629 - 634
  • [46] Dose-Dependent Impact of Bee Pollen Supplementation on Macroscopic and Microscopic Structure of Femoral Bone in Rats
    Martiniakova, Monika
    Bobonova, Ivana
    Toman, Robert
    Galik, Branislav
    Bauerova, Maria
    Omelka, Radoslav
    ANIMALS, 2021, 11 (05):
  • [47] Dose-dependent effects of magnesium supplementation on serum and intracellular magnesium concentrations in healthy horses
    Stockel, Sabita Diana
    Mueller, Eva
    Winter, Judith C.
    Sponder, Gerhard
    Aschenbach, Jorg R.
    Pieper, Laura
    Gehlen, Heidrun
    PFERDEHEILKUNDE, 2019, 35 (06): : 529 - 534
  • [48] Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice
    Peters, S. J.
    Van Helvoort, A.
    Kegler, D.
    Argiles, J. M.
    Luiking, Y. C.
    Laviano, A.
    Van Bergenhenegouwen, J.
    Deutz, N. E. P.
    Haagsman, H. P.
    Gorselink, M.
    Van Norren, K.
    ONCOLOGY REPORTS, 2011, 26 (01) : 247 - 254
  • [49] Dose-dependent effects of phytoestrogens on bone
    Dang, ZC
    Lowik, C
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2005, 16 (05): : 207 - 213
  • [50] DOSE-DEPENDENT EFFECTS OF WARFARIN ON FIBRINOLYSIS
    LAMB, J
    MARSH, NA
    FARRELL, RJ
    THROMBOSIS AND HAEMOSTASIS, 1983, 50 (01) : 296 - 296
12345