AN ASSAY FOR COMPLEMENT FACTOR-B IN SPECIES AT DIFFERENT LEVELS OF EVOLUTION

被引：4
|
作者：
JENSEN, LB
KOCH, C
机构：
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1991年 / 15卷 / 03期
关键词：
COMPLEMENT FACTOR-B; EVOLUTION; C3; CONVERTASE;
D O I：
10.1016/0145-305X(91)90008-M
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
The alternative complement pathway is regarded as the evolutionary ancestral complement system. It is therefore of interest to analyze and characterize factor B of the alternative complement pathway in animals at different levels of evolution. We describe a functional assay which is based on the interaction of factor B from various animal species with Cobra Venom Factor, the snake C3b-analog. The signal system in the assay is C3-conversion in factor B-depleted chicken serum. The results show that a functional C3-convertase can be created with factor B from mammals, aves, and amphibians.
引用
收藏
页码：173 / 179
页数：7
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