THE CHARACTERIZATION OF SYNTHETIC BY-PRODUCTS BY B/E LINKED SCANNING AND HIGH-RESOLUTION THERMOSPRAY MASS-SPECTROMETRY

被引：4
|
作者：
DINALLO, RM
DAVIDSON, WC
HANSEN, GE
机构：
[1] Department of Analytical Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Research and Development Center, Ridgefield, Connecticut
来源：
BIOLOGICAL MASS SPECTROMETRY | 1991年 / 20卷 / 05期
关键词：
D O I：
10.1002/bms.1200200506
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Characterization of unknown synthetic by-products from a test synthesis of the experimental inhibitor of HIV-1 reverse transcriptase, BI-RG-587, is presented. Seven impurities were separated and characterized by thermospray liquid chromatography/mass spectrometry using low-resolution, high-resolution, and B/E linked scanning methods. The high-resolution mass measurements which were obtained were accurate to within 10 ppm of structures proposed for synthetic by-products present at the 0.1% level. Linked scans produced daughter ion spectra for each impurity to further aid in the characterization.
引用
收藏
页码：268 / 274
页数：7
相关论文
共 50 条
  • [21] Characterization of imazamox degradation by-products by using liquid chromatography mass spectrometry and high-resolution Fourier transform ion cyclotron resonance mass spectrometry
    Harir, M.
    Frommberger, M.
    Gaspar, A.
    Martens, D.
    Kettrup, A.
    El Azzouzi, M.
    Schmitt-Kopplin, Ph.
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2007, 389 (05) : 1459 - 1467
  • [22] Characterization of imazamox degradation by-products by using liquid chromatography mass spectrometry and high-resolution Fourier transform ion cyclotron resonance mass spectrometry
    M. Harir
    M. Frommberger
    A. Gaspar
    D. Martens
    A. Kettrup
    M. El Azzouzi
    Ph. Schmitt-Kopplin
    Analytical and Bioanalytical Chemistry, 2007, 389 : 1459 - 1467
  • [23] HIGH-RESOLUTION MASS-SPECTROMETRY - BUFADIENOLIDES .1.
    BROWN, P
    KAMANO, Y
    PETTIT, GR
    ORGANIC MASS SPECTROMETRY, 1972, 6 (01): : 47 - &
  • [24] PRECISION OF FRAGMENTATION PATTERNS IN HIGH-RESOLUTION MASS-SPECTROMETRY
    BROWN, WF
    FISHER, IP
    TALANTA, 1972, 19 (06) : 798 - &
  • [25] HIGH-RESOLUTION MASS-SPECTROMETRY - BUFADIENOLIDES .2.
    BROWN, P
    PETTIT, GR
    KAMANO, Y
    ORGANIC MASS SPECTROMETRY, 1972, 6 (06): : 613 - &
  • [26] RAPID SEQUENCING OF OLIGONUCLEOTIDES BY HIGH-RESOLUTION MASS-SPECTROMETRY
    LITTLE, DP
    CHORUSH, RA
    SPEIR, JP
    SENKO, MW
    KELLEHER, NL
    MCLAFFERTY, FW
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (11) : 4893 - 4897
  • [27] High-resolution mass-spectrometry analysis of peptides and proteins
    Nikolaev, E. N.
    Popov, I. A.
    Kononikhin, A. S.
    Indeykina, M. I.
    Kukaev, E. N.
    RUSSIAN CHEMICAL REVIEWS, 2012, 81 (11) : 1051 - 1070
  • [28] HIGH-RESOLUTION TANDEM MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    LOO, JA
    QUINN, JP
    RYU, SI
    HENRY, KD
    SENKO, MW
    MCLAFFERTY, FW
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) : 286 - 289
  • [29] HIGH-RESOLUTION MASS-SPECTROMETRY IN CLINICAL-CHEMISTRY
    HUTTERER, F
    ROBOZ, J
    KRUMAN, D
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1972, 29 : 177 - &
  • [30] SINGLE ION COUNTING IN HIGH-RESOLUTION MASS-SPECTROMETRY
    WACHI, FM
    GILMARTIN, DE
    REVIEW OF SCIENTIFIC INSTRUMENTS, 1977, 48 (06): : 703 - 705
12345