THE CHARACTERIZATION OF SYNTHETIC BY-PRODUCTS BY B/E LINKED SCANNING AND HIGH-RESOLUTION THERMOSPRAY MASS-SPECTROMETRY

被引：4
|
作者：
DINALLO, RM
DAVIDSON, WC
HANSEN, GE
机构：
[1] Department of Analytical Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Research and Development Center, Ridgefield, Connecticut
来源：
BIOLOGICAL MASS SPECTROMETRY | 1991年 / 20卷 / 05期
关键词：
D O I：
10.1002/bms.1200200506
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Characterization of unknown synthetic by-products from a test synthesis of the experimental inhibitor of HIV-1 reverse transcriptase, BI-RG-587, is presented. Seven impurities were separated and characterized by thermospray liquid chromatography/mass spectrometry using low-resolution, high-resolution, and B/E linked scanning methods. The high-resolution mass measurements which were obtained were accurate to within 10 ppm of structures proposed for synthetic by-products present at the 0.1% level. Linked scans produced daughter ion spectra for each impurity to further aid in the characterization.
引用
收藏
页码：268 / 274
页数：7
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