BLOOD-PRESSURE EFFECTS OF ACUTE INTRAVENOUS RENIN OR ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITION IN ESSENTIAL-HYPERTENSION

被引：0

作者：

AZIZI, M ^{[1
]}

GUYENE, TT ^{[1
]}

CHATELLIER, G ^{[1
]}

MENARD, J ^{[1
]}

机构：

[1] INSERM, U367, PARIS, FRANCE

来源：

JOURNAL OF HYPERTENSION | 1994年 / 12卷 / 04期

关键词：

ESSENTIAL HYPERTENSION; RENIN DEPENDENCE; REMIKIREN; CAPTOPRIL;

D O I：

暂无

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective: To assess the participation of the renin-angiotensin system in the blood pressure regulation of essential hypertensive patients through acute specific renin inhibition. Design and methods: Fifty-three consecutive untreated hypertensive patients (mean +/- SD age 55 +/- 10 years, 42 male) were investigated on their usual sodium diet in a 3-h protocol. The first 11 patients did not receive any drug, the following 20 patients ingested a single oral dose of captopril (1 mg/kg) and the last 22 patients received a renin inhibitor infusion (remikiren; 1 mg/kg over 60 min).

引用

页码：419 / 427

页数：9

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