BLOOD-PRESSURE EFFECTS OF ACUTE INTRAVENOUS RENIN OR ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITION IN ESSENTIAL-HYPERTENSION

被引：0
|
作者：
AZIZI, M [1 ]
GUYENE, TT [1 ]
CHATELLIER, G [1 ]
MENARD, J [1 ]
机构：
[1] INSERM, U367, PARIS, FRANCE
来源：
JOURNAL OF HYPERTENSION | 1994年 / 12卷 / 04期
关键词：
ESSENTIAL HYPERTENSION; RENIN DEPENDENCE; REMIKIREN; CAPTOPRIL;
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Objective: To assess the participation of the renin-angiotensin system in the blood pressure regulation of essential hypertensive patients through acute specific renin inhibition. Design and methods: Fifty-three consecutive untreated hypertensive patients (mean +/- SD age 55 +/- 10 years, 42 male) were investigated on their usual sodium diet in a 3-h protocol. The first 11 patients did not receive any drug, the following 20 patients ingested a single oral dose of captopril (1 mg/kg) and the last 22 patients received a renin inhibitor infusion (remikiren; 1 mg/kg over 60 min).
引用
收藏
页码：419 / 427
页数：9
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