HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND CAPILLARY GEL-ELECTROPHORESIS AS APPLIED TO ANTISENSE DNA

被引：0
|
作者：
COHEN, AS
VILENCHIK, M
DUDLEY, JL
GEMBORYS, MW
BOURQUE, AJ
机构：
来源：
JOURNAL OF CHROMATOGRAPHY | 1993年 / 638卷 / 02期
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中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Reversed-phase and ion-exchange HPLC are compared with both slab gel and capillary gel electrophoresis tor the separation of antisense phosphorothioate oligomers. The chromatographic separations were found to be markedly inferior to the electrophoretic separations, especially for oligomers greater than 20 bases in length. The potential of gel high-performance capillary electrophoresis for the analysis of phosphorothioate analogues is shown.
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页码：293 / 301
页数：9
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