EFFECT OF TRUNCAL VAGOTOMY ON TAUROCHOLATE CHOLERESIS AND SECRETIN CHOLERESIS

Mongrel dogs were prepared for cholecystectomy, chronic bile and gastric fistulas and pyloroplasty. Taurocholate and secretin choleresis were observed before and after truncal vagotomy. Vagotomy caused minor decreases in bicarbonate output and an increase in chloride output but had no influence on bile flow, bile salt concentration or bile salt output. Vagotomy had no influence on secretin choleresis. Previously observed reductions in bile salt secretion after vagotomy are apparently due to some mechanism other than the influence of vagotomy on hepatic bile secretion.