REDUCED VIRULENCE OF CANDIDA-ALBICANS PHR1 MUTANTS

被引：66
|
作者：
GHANNOUM, MA
SPELLBERG, B
SAPORITOIRWIN, SM
FONZI, WA
机构：
[1] GEORGETOWN UNIV,MED CTR,SCH MED,DEPT IMMUNOL & MICROBIOL,WASHINGTON,DC 20007
[2] UNIV CALIF LOS ANGELES,HARBOR RES & EDUC INST,ST JOHNS CARDIOVASC RES CTR,DIV INFECT DIS,TORRANCE,CA 90509
[3] UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA 90024
[4] UNIV CALIF IRVINE,CALIF COLL MED,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717
来源：
INFECTION AND IMMUNITY | 1995年 / 63卷 / 11期
关键词：
D O I：
10.1128/IAI.63.11.4528-4530.1995
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Candida albicans mutants lacking PHR1 exhibit a pH-dependent morphogenic defect which is expressed at pH 7.5, a pH comparable to that of mammalian blood (S. M. Saporito-Irwin, C. E. Birse, P. S. Sypherd, and W.A. Fonzi, Mol. Cell. Biol. 15:601-613, 1995). The in vivo relevance of this expression pattern was tested in a mouse model of systemic candidiasis. A phr1/phr1 mutant was found to be less virulent than an isogenic Phr1(+) strain and exhibited altered morphological development in vivo. These results indicate that PHR1 contributes to the virulence of C. albicans.
引用
收藏
页码：4528 / 4530
页数：3
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