DEVELOPMENT OF NEW DNA-BINDING AND CLEAVING MOLECULES - DESIGN, SYNTHESIS AND ACTIVITY OF A BISDIAZONIUM SALT

被引：22
|
作者：
ARYA, DP [1 ]
WARNER, PM [1 ]
JEBARATNAM, DJ [1 ]
机构：
[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期
关键词：
D O I：
10.1016/S0040-4039(00)61485-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 mu M. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving reagent.
引用
收藏
页码：7823 / 7826
页数：4
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