DEVELOPMENT OF NEW DNA-BINDING AND CLEAVING MOLECULES - DESIGN, SYNTHESIS AND ACTIVITY OF A BISDIAZONIUM SALT

被引:22
|
作者
ARYA, DP [1 ]
WARNER, PM [1 ]
JEBARATNAM, DJ [1 ]
机构
[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115
关键词
D O I
10.1016/S0040-4039(00)61485-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 mu M. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving reagent.
引用
收藏
页码:7823 / 7826
页数:4
相关论文
共 50 条
  • [1] New triruthenium clusters as photoinduced DNA-binding and cleaving agents
    Hwu, JR
    Lu, KL
    Yu, SF
    Yu, LJ
    Kumaresan, S
    Lin, KJ
    Tsay, SC
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2002, 75 (05) : 457 - 461
  • [2] DESIGN AND SYNTHESIS OF SEQUENCE SPECIFIC DNA CLEAVING MOLECULES
    SCHULTZ, PG
    DERVAN, PB
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 189 (APR-): : 141 - ORGN
  • [3] DESIGN OF SEQUENCE SPECIFIC DNA-BINDING MOLECULES
    DERVAN, PB
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1986, 192 : 122 - ORGN
  • [4] SYNTHESIS OF A NEW COPPER COMPLEX OF A MACROCYCLIC COMPOUND CONSISTING OF 1,10-PHENANTHROLINE, AND ITS DNA-BINDING AND CLEAVING ACTIVITY
    HIRAI, M
    SHINOZUKA, K
    SAWAI, H
    OGAWA, S
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1994, 67 (04) : 1147 - 1155
  • [5] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES
    DERVAN, PB
    SCIENCE, 1986, 232 (4749) : 464 - 471
  • [6] Design and synthesis of a new class of DNA-binding dinuclear ruthenium complexes
    van der Schilden, K
    Velders, AH
    Haasnoot, JG
    Reedijk, J
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 86 (01) : 466 - 466
  • [7] Design, synthesis, DNA-binding and cytotoxicity evaluation of new potential combilexines
    Hotzel, C
    Marotto, A
    Pindur, U
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (05) : 367 - 378
  • [8] SYNTHESIS, DNA-BINDING AND BIOLOGICAL-ACTIVITY OF OXAZOLOPYRIDOCARBAZOLE-NETROPSIN HYBRID MOLECULES
    MRANI, D
    GOSSELIN, G
    AUCLAIR, C
    BALZARINI, J
    DECLERCQ, E
    PAOLETTI, C
    IMBACH, JL
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1991, 26 (05) : 481 - 488
  • [9] NEW DNA-CLEAVING AND CROSS-LINKING REAGENTS - BISDIAZONIUM SALTS AND THEIR DERIVATIVES
    KUGABALASOORIAR, S
    ARYA, DP
    DEVLIN, TA
    JEBARATNAM, DJ
    WARNER, PM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 337 - ORGN
  • [10] Design of new DNA-binding steroidal peptidomimetics
    Verzele, D.
    Madder, A.
    JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 141 - 141