DEVELOPMENT OF NEW DNA-BINDING AND CLEAVING MOLECULES - DESIGN, SYNTHESIS AND ACTIVITY OF A BISDIAZONIUM SALT

被引：22

作者：

ARYA, DP ^{[1
]}

WARNER, PM ^{[1
]}

JEBARATNAM, DJ ^{[1
]}

机构：

[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61485-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 mu M. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving reagent.

引用

页码：7823 / 7826

页数：4

共 50 条

[1] New triruthenium clusters as photoinduced DNA-binding and cleaving agents
Hwu, JR
Lu, KL
Yu, SF
Yu, LJ
Kumaresan, S
Lin, KJ
Tsay, SC
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2002, 75 (05) : 457 - 461
[2] DESIGN AND SYNTHESIS OF SEQUENCE SPECIFIC DNA CLEAVING MOLECULES
SCHULTZ, PG
DERVAN, PB
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 189 (APR-): : 141 - ORGN
[3] DESIGN OF SEQUENCE SPECIFIC DNA-BINDING MOLECULES
DERVAN, PB
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1986, 192 : 122 - ORGN
[4] SYNTHESIS OF A NEW COPPER COMPLEX OF A MACROCYCLIC COMPOUND CONSISTING OF 1,10-PHENANTHROLINE, AND ITS DNA-BINDING AND CLEAVING ACTIVITY
HIRAI, M
SHINOZUKA, K
SAWAI, H
OGAWA, S
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1994, 67 (04) : 1147 - 1155
[5] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES
DERVAN, PB
SCIENCE, 1986, 232 (4749) : 464 - 471
[6] Design and synthesis of a new class of DNA-binding dinuclear ruthenium complexes
van der Schilden, K
Velders, AH
Haasnoot, JG
Reedijk, J
JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 86 (01) : 466 - 466
[7] Design, synthesis, DNA-binding and cytotoxicity evaluation of new potential combilexines
Hotzel, C
Marotto, A
Pindur, U
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (05) : 367 - 378
[8] SYNTHESIS, DNA-BINDING AND BIOLOGICAL-ACTIVITY OF OXAZOLOPYRIDOCARBAZOLE-NETROPSIN HYBRID MOLECULES
MRANI, D
GOSSELIN, G
AUCLAIR, C
BALZARINI, J
DECLERCQ, E
PAOLETTI, C
IMBACH, JL
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1991, 26 (05) : 481 - 488
[9] NEW DNA-CLEAVING AND CROSS-LINKING REAGENTS - BISDIAZONIUM SALTS AND THEIR DERIVATIVES
KUGABALASOORIAR, S
ARYA, DP
DEVLIN, TA
JEBARATNAM, DJ
WARNER, PM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 337 - ORGN
[10] Design of new DNA-binding steroidal peptidomimetics
Verzele, D.
Madder, A.
JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 141 - 141

← 1 2 3 4 5 →