CLONING OF A CDNA-ENCODING A RECEPTOR RELATED TO THE FORMYL PEPTIDE RECEPTOR OF HUMAN NEUTROPHILS

被引：38
|
作者：
PEREZ, HD [1 ]
HOLMES, R [1 ]
KELLY, E [1 ]
MCCLARY, J [1 ]
ANDREWS, WH [1 ]
机构：
[1] BERLEX BIOSCI,DEPT MOLEC BIOL,S SAN FRANCISCO,CA 94080
来源：
GENE | 1992年 / 118卷 / 02期
关键词：
INFLAMMATION; CHEMOTAXIS; G-PROTEIN; HL-60; CELLS; BONE MARROW;
D O I：
10.1016/0378-1119(92)90208-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We cloned a cDNA (RFP) encoding a receptor (RFP) related (70% overall nucleotide homology) to the formyl peptide receptor of human neutrophils (hFPR). RFP is a seven-transmembrane-domain receptor and its distribution is limited to myeloid cells. Domain sequence comparison with hFPR reveals highly conserved regions and provides clues to putative domains involved in ligand binding and receptor desensitization.
引用
收藏
页码：303 / 304
页数：2
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