MATURATION OF MOUSE MAMMARY-TUMOR VIRUS ENVELOPE PROTEIN IS BLOCKED BY A SPECIFIC POINT MUTATION

被引:1
|
作者
BEDGOOD, RM
SNIDER, LD
STALLCUP, MR
机构
[1] UNIV SO CALIF,HLTH SCI CTR,DEPT PATHOL,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,HLTH SCI CTR,DEPT BIOCHEM,LOS ANGELES,CA 90033
关键词
D O I
10.1016/0042-6822(92)90723-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Expression of a mouse mammary tumor virus (MMTV) envelope gene, ENV2, in COS-7 cells resulted in the synthesis of a precursor protein Pr74 that underwent complete proteolytic processing to the mature envelope species gp52 and gp33. In contrast, expression of a second MMTV envelope gene, ENV1, in COS-7 cells resulted in the synthesis of a precursor protein Pr74 that failed to undergo proteolytic processing to the mature products. Expression and sequencing of various chimeric ENV1/ENV2 genes determined that a single glycine-to-glutamic acid mutation at position 54 was responsible for the nonprocessable phenotype of ENV1-encoded Pr74. The significance of this point mutation in relation to the requirements for precursor protein folding and maturation are discussed. © 1992.
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页码:393 / 396
页数:4
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