CENTRIFUGAL COUNTERCURRENT CHROMATOGRAPHY, A PROMISING MEANS OF MEASURING PARTITION-COEFFICIENTS

被引：36
|
作者：
VALLAT, P
ELTAYAR, N
TESTA, B
SLACANIN, I
MARSTON, A
HOSTETTMANN, K
机构：
[1] UNIV LAUSANNE,ECOLE PHARM,INST CHIM THERAPEUT,PL CHATEAU,CH-1005 LAUSANNE,SWITZERLAND
[2] UNIV LAUSANNE,ECOLE PHARM,INST PHARMACOGNOSIE & PHYTOCHIM,CH-1005 LAUSANNE,SWITZERLAND
来源：
JOURNAL OF CHROMATOGRAPHY | 1990年 / 504卷 / 02期
关键词：
D O I：
10.1016/S0021-9673(01)89544-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Centrifugal counter-current chromatography (CCCC) was examined as a means of measuring lipophilicity values. Using an aqueous buffer as the stationary phase and 1-octanol as the eluent, seventeen solutes of widely different structure and of log Doct [log (distribution coefficient) at pH 7.41 spanning 2.5 units were examined. A very good correlation was found with literature log P [log (partition coefficient) of neutral species] values measured by the classical shake-flask method. The efficiency and precision of the CCCC method makes it a promising technique for measuring lipophilicity. © 1990.
引用
收藏
页码：411 / 419
页数：9
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