RHEUMATOID-ARTHRITIS - OPPOSING ACTIONS OF HEMATOPOIETIC GROWTH-FACTORS AND SLOW-ACTING ANTIRHEUMATIC DRUGS

被引：91
|
作者：
HAMILTON, JA
机构：
[1] University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville
来源：
LANCET | 1993年 / 342卷 / 8870期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0140-6736(93)91653-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pathogenesis of rheumatoid arthritis and the mode of action of anti-rheumatic drugs are unknown. This hypothesis proposes that haemopoietic growth factors (colony stimulating factors [CSFs]) have an important role in rheumatoid arthritis as regulators of myelopoiesis and as activators of inflammatory leucocytes. It also suggests that slow-acting anti-rheumatic drugs may work by inhibiting myelopoiesis. This opposition to one of the actions of the CSFs would result in fewer inflammatory cells in the inflamed joints.
引用
收藏
页码：536 / 539
页数：4
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