SYNTHESIS OF DEUTERIUM-LABELED AND TRITIUM-LABELED METHYLENEDIPHOSPHONIC ACID

A facile method for preparing of tritiated MDP at specific activities comparable to those of available tritiated water and in ample quantity both for further synthetic incorporation into nucleotides and for metabolic studies has been suggested. We chose to pilot this preparation by investigation of the pattern and extent of deuteriation of tetraethyl methylenediphosphonate, basing our approach on the known reactions of tetraethyl sodiomethylenediphosphonate with halides, with halogens, and with oxygen.