OPTIMIZATION OF FED-BATCH CULTURE OF HYBRIDOMA CELLS USING DYNAMIC-PROGRAMMING - SINGLE AND MULTI FEED CASES

被引：0
|
作者：
DETREMBLAY, M
PERRIER, M
CHAVARIE, C
ARCHAMBAULT, J
机构：
[1] ECOLE POLYTECH, MONTREAL H3C 3A7, QUEBEC, CANADA
[2] PULP & PAPER RES INST CANADA, MONTREAL H3A 2A7, QUEBEC, CANADA
[3] BIOTECHNOL RES INST, MONTREAL, QUEBEC, CANADA
来源：
BIOPROCESS ENGINEERING | 1992年 / 7卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The optimization of fed-batch culture of hybridoma cells is accomplished on a mathematical model using dynamic programming. Optimal feed trajectories are found using a seventh order model for a single feed stream containing both glucose and glutamine and for two separate feed streams of glucose and glutamine. Compared to a constant feed rate, optimal trajectories can improve the final MAb concentration by 11% for the single feed case and by 20% for the multifeed case. Higher MAb concentrations can be expected for fed-batch optimization with feed enriched in nutrients.
引用
收藏
页码：229 / 234
页数：6
相关论文
共 50 条
  • [41] THE DEVELOPMENT OF OPTIMAL FEEDING STRATEGIES IN A FED-BATCH HYBRIDOMA CULTURE USING A NOVEL STRUCTURED KINETIC-MODEL
    BATT, BC
    KOMPALA, DS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 115 - MBTD
  • [42] Optimization of arachidonic acid production by fed-batch culture of Mortierella alpina based on dynamic analysis
    Zhu, M
    Yu, LJ
    Li, W
    Zhou, PP
    Li, CY
    ENZYME AND MICROBIAL TECHNOLOGY, 2006, 38 (06) : 735 - 740
  • [43] MODELING, OPTIMIZATION AND REALIZATION OF FED-BATCH CULTURE USING THE SPECIFIC GROWTH-RATE
    SHIOYA, S
    SHIMIZU, H
    PATOOMPRON, C
    SUGA, K
    KAGAKU KOGAKU RONBUNSHU, 1991, 17 (03) : 572 - 578
  • [44] Efficient optimization of time-varying inputs in a fed-batch cell culture process using design of dynamic experiments
    Luo, Yu
    Stanton, Duane A.
    Sharp, Rachel C.
    Parrillo, Alexis J.
    Morgan, Kelsey T.
    Ritz, Diana B.
    Talwar, Sameer
    BIOTECHNOLOGY PROGRESS, 2023, 39 (06)
  • [45] Optimal control of a fed-batch bioreactor using simulation-based approximate dynamic programming
    Peroni, CV
    Kaisare, NS
    Lee, JH
    IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY, 2005, 13 (05) : 786 - 790
  • [46] Fed-batch culture optimization of a growth-associated hybridoma cell line in chemically defined protein-free media
    Gong, Xianghui
    Li, Dongxiao
    Li, Xuesen
    Fang, Qiangyi
    Han, Xiangzong
    Wu, Yuyin
    Yang, Shengli
    Shen, Bing Q.
    CYTOTECHNOLOGY, 2006, 52 (01) : 25 - 38
  • [47] Fed-batch culture optimization of a growth-associated hybridoma cell line in chemically defined protein-free media
    Xianghui Gong
    Dongxiao Li
    Xuesen Li
    Qiangyi Fang
    Xiangzong Han
    Yuyin Wu
    Shengli Yang
    Bing Q. Shen
    Cytotechnology, 2006, 52 : 25 - 38
  • [48] Optimization of fed-batch Saccharomyces cerevisiae fermentation using dynamic flux balance models
    Hjersted, Jared L.
    Henson, Michael A.
    BIOTECHNOLOGY PROGRESS, 2006, 22 (05) : 1239 - 1248
  • [49] Automated dynamic fed-batch process and media optimization for high productivity cell culture process development
    Lu, Franklin
    Toh, Poh Choo
    Burnett, Iain
    Li, Feng
    Hudson, Terry
    Amanullah, Ashraf
    Li, Jincai
    BIOTECHNOLOGY AND BIOENGINEERING, 2013, 110 (01) : 191 - 205
  • [50] Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design
    Selvarasu, Suresh
    Kim, Do Yun
    Karimi, Iftekhar A.
    Lee, Dong-Yup
    JOURNAL OF BIOTECHNOLOGY, 2010, 150 (01) : 94 - 100
12345