Acute fatty liver of pregnancy is an uncommon entity, which affects women during the last trimester of pregnancy. It is characterized by a prodromic period of symptoms such as uneasiness, nausea, epigastric pain, and jaundice. Analysis shows high levels of bilirubin, transaminase, hypoglycaemia and prolonged clotting time. Treatment is by ending the pregnancy immediately. Hepatic biopsy is useful for atypical cases. The maternal and fetal mortality rate is 20%. We analyze the clinical presentation, analytical parameters, treatment and evolution of this disease with the report of a clinical case in our hospital, as a contribution to the scarcity of available publications.