ADENYLATE-CYCLASE ACTIVITY IN CYANOBACTERIA - ACTIVATION BY CA-2+-CALMODULIN AND A CALMODULIN-LIKE ACTIVITY

被引：14
|
作者：
BIANCHINI, GM
PASTINI, AC
MUSCHIETTI, JP
TELLEZINON, MT
MARTINETTO, HE
TORRES, HN
FLAWIA, MM
机构：
[1] CONSEJO NACL INVEST CIENT & TECN, INST INVEST & INGN GENET & BIOL MOLEC, OBLIGADO 2490, RA-1428 BUENOS AIRES, ARGENTINA
[2] FAC CIENCIAS EXACTAS & NAT BUENOS AIRES, BUENOS AIRES, ARGENTINA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1055卷 / 01期
关键词：
(Anabaena); (Cyanobacteria); Adenylate cyclase; Calmodulin; Calmodulin-like activity; cyclic AMP;
D O I：
10.1016/0167-4889(90)90093-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An adenylate cyclase activity was partially characterized in the cyanobacterium Anabaena sp. The enzyme activity is found in soluble cell fractions and shows an apparent molecular weight of about 183 400. This adenylate cyclase is activated by Ca2+ and bovine brain or spinach calmodulin and it is inhibited by EGTA and some phenothiazine derivatives. Furthermore, Anabaena sp. extracts contain a calmodulin-like activity which stimulates bovine brain cyclic AMP phosphodiesterase and the Anabaena adenylate cyclase. EGTA and phenothiazine derivatives block the cyano-bacterial modulator effect. © 1990.
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页码：75 / 81
页数：7
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