Treatment of early-stage HER2+ breast cancer-an evolving field

被引：8
|
作者：
Ferreira, Arlindo R. [1 ,2 ,3 ]
Saini, Kamal S. [4 ]
Metzger-Filho, Otto [1 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02215 USA
[2] Univ Lisbon, Hosp Santa Maria, P-1649035 Lisbon, Portugal
[3] Univ Lisbon, Inst Med Mol, P-1649035 Lisbon, Portugal
[4] Univ Libre Bruxelles, Inst Jules Bordet, B-1000 Brussels, Belgium
来源：
ECANCERMEDICALSCIENCE | 2015年 / 9卷
关键词：
breast neoplasm; trastuzumab; neoadjuvant therapy; adjuvant therapy; antibodies; monoclonal; humanised;
D O I：
10.3332/ecancer.2015.523
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The evolving field of HER2-targeted therapy has significantly improved the outcome of women diagnosed with HER2-positive invasive breast cancer. In this review, we sought to summarise the efficacy of trastuzumab-based regimens in the adjuvant and neoadjuvant setting with a special emphasis on relevant clinical questions: treatment duration, sequence of trastuzumab administration, toxicity, the role of anthracycline-based regimens, and optimal management of small HER2+ tumours. Controversial topics are discussed taking into consideration the development of modern anti-HER2 agents.
引用
收藏
页数：15
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