The Effect of Muscarinic Receptor Modulators on the Antinociception Induced by CB2 Receptor Agonist, JWH133 in Mice

被引：1
|
作者：
Alipour, M. [1 ]
Fekrmandi, F. [2 ]
Onsori, S. [1 ]
Tabrizian, P. [1 ]
Jafari, M. R. [1 ]
机构：
[1] Zanjan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Zanjan 45147, Iran
[2] McGill Univ, Dept Med, Montreal, PQ, Canada
来源：
DRUG RESEARCH | 2016年 / 66卷 / 11期
关键词：
antinociception; JWH-133; pilocarpine; atropine; formalin test; mice;
D O I：
10.1055/s-0042-112365
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
There is no published study regarding the interaction between muscarinic receptor modulators and antinociception induced by cannabinoid receptor (CB2) agonist. The effect of pilocarpine (a muscarinic agonist) and atropine (a muscarinic antagonist) on JWH-133 (a CB2 agonist) induced analgesia in mice was studied. First the analgesic effect of JWH-133 (0.001-1mg/Kg) or pilocarpine (2.5-20mg/kg) or atropine (0.2-5mg/kg) was evaluated. Subsequently, the effect of co-administration of pilocarpine (2.5mg/kg) or atropine (5mg/kg) and JWH-133 (0.001-1mg/Kg) were studied too. JWH-133 and pilocarpine provoked antinociception in mice but atropine did not. Pilocarpine potentiated the analgesic effect of JWH-133 but atropine antagonized that. It can be concluded that JWH-133 induced antinociception is affected by muscarinic receptor modulators in mice.
引用
收藏
页码：597 / 602
页数：6
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