MODELING OF DRUG-RELEASE FROM POLYMER MATRICES - EFFECT OF DRUG LOADING

被引：0
|
作者：
ELARINI, SK
LEUENBERGER, H
机构：
[1] UNIV BASEL, SCH PHARM, CH-4051 BASEL, SWITZERLAND
[2] NATL RES CTR, CAIRO, EGYPT
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 121卷 / 02期
关键词：
DRUG RELEASE; POLYMER MATRIX; MATHEMATICAL MODELING; DRUG LOADING; PERCOLATION THEORY; CRITICAL PERCOLATION THRESHOLD;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The release kinetics of caffeine and potassium chloride (KC1) representing poorly soluble and water-soluble drugs from polyvinylpyrrolidone (PVP) matrices were studied using different mathematical models. Dissolution parameters obtained from the release data were employed to characterize the effect of drug loading on the release kinetics. The deviations observed from the predicted values for these parameters were explained using percolation theory as well as the release kinetics of the matrix material itself.
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页码：141 / 148
页数：8
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