INDUCTION OF CYP3A ENZYMES IN HUMAN AND RAT HEPATOCYTE CULTURES

被引：8
|
作者：
WILLIAMS, JA
CHENERY, RJ
HAWKSWORTH, GM
机构：
[1] UNIV ABERDEEN, DEPT BIOMED SCI, ABERDEEN AB9 2ZD, SCOTLAND
[2] SMITHKLINE BEECHAM PHARMACEUT, DEPT DRUG METAB & PHARMACOKINET, WELWYN GARDEN CITY AL6 9AR, HERTS, ENGLAND
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 1994年 / 22卷 / 02期
关键词：
D O I：
10.1042/bst022131s
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：S131 / S131
页数：1
相关论文
共 50 条
  • [21] Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
    Ines Fuchs
    Verena Hafner-Blumenstiel
    Christoph Markert
    Jürgen Burhenne
    Johanna Weiss
    Walter Emil Haefeli
    Gerd Mikus
    European Journal of Clinical Pharmacology, 2013, 69 : 507 - 513
  • [22] Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells
    Matsunaga, Tamihide
    Maruyama, Masataka
    Matsubara, Tsutomu
    Nagata, Kiyoshi
    Yamazoe, Yasushi
    Ohmori, Shigeru
    DRUG METABOLISM AND PHARMACOKINETICS, 2012, 27 (06) : 653 - 657
  • [23] Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity
    Fuchs, Ines
    Hafner-Blumenstiel, Verena
    Markert, Christoph
    Burhenne, Juergen
    Weiss, Johanna
    Haefeli, Walter Emil
    Mikus, Gerd
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 69 (03) : 507 - 513
  • [24] Comparative induction of CYP3A and CYP2B in rat liver by 3-benzoylpyridine and metyrapone
    Murray, M
    Sefton, RM
    Martini, R
    Butler, AM
    CHEMICO-BIOLOGICAL INTERACTIONS, 1998, 113 (03) : 161 - 173
  • [25] Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat Hepatocytes
    Nishimura, Masuhiro
    Koeda, Akiko
    Suganuma, Yasuyuki
    Suzuki, Emako
    Shimizu, Takefumi
    Nakayama, Mitsuo
    Satoh, Tetsuo
    Narimatsu, Shizuo
    Naito, Shinsaku
    DRUG METABOLISM AND PHARMACOKINETICS, 2007, 22 (03) : 178 - 186
  • [26] Induction of Hepatic CYP3A Enzymes by Pregnancy-Related Hormones: Studies in Human Hepatocytes and Hepatic Cell Lines
    Papageorgiou, Ioannis
    Grepper, Susan
    Unadkat, Jashvant D.
    DRUG METABOLISM AND DISPOSITION, 2013, 41 (02) : 281 - 290
  • [27] Effect of troglitazone on CYP3A protein and activity in primary cultures of human hepatocytes
    Ramachandran, V
    Kostrubsky, VE
    Zhang, S
    Strom, SC
    Venkataraman, R
    FASEB JOURNAL, 1999, 13 (05): : A1013 - A1013
  • [28] CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition
    Kharasch, ED
    Thummel, KE
    Watkins, PB
    MOLECULAR INTERVENTIONS, 2005, 5 (03) : 151 - +
  • [29] ETHANOL AND ISOPENTANOL INCREASE CYP3A AND CYP2E IN PRIMARY CULTURES OF HUMAN HEPATOCYTES
    KOSTRUBSKY, VE
    STROM, SC
    WOOD, SG
    WRIGHTON, SA
    SINCLAIR, PR
    SINCLAIR, JF
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 322 (02) : 516 - 520
  • [30] INDUCTION OF METALLOTHIONEIN IN PRIMARY RAT HEPATOCYTE CULTURES
    KLAASSEN, CD
    LIU, J
    METHODS IN ENZYMOLOGY, 1991, 205 : 567 - 574
12345