MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND SUSCEPTIBILITY TO SYSTEMIC LUPUS-ERYTHEMATOSUS IN NORTHERN INDIA

被引：11
|
作者：
MEHRA, NK
PANDE, I
TANEJA, V
UPPAL, SS
SAXENA, SP
KUMAR, A
MALAVIYA, AN
机构：
[1] AIIMS,DEPT MED,NEW DELHI 110029,INDIA
[2] ALL INDIA INST MED SCI,DEPT MED,HISTOCOMPATABIL & IMMUNOGENET UNIT,NEW DELHI 29,INDIA
[3] ALL INDIA INST MED SCI,DEPT MED,CLIN IMMUNOL UNIT,NEW DELHI 29,INDIA
来源：
LUPUS | 1993年 / 2卷 / 05期
关键词：
MAJOR HISTOCOMPATIBILITY COMPLEX (MHC); SLE; ASIAN INDIANS;
D O I：
10.1177/096120339300200506
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.
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页码：313 / 314
页数：2
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