Investigation of Sarcopenia and Its Association with Cardiometabolic Risk Factors in Elderly Subjects

被引:14
|
作者
Kim, Jung Hee [1 ]
Bo, Yul Hwang [1 ]
Hong, Eun Shil [1 ]
Ohn, Jung Hun [1 ]
Kim, Chi Hoon [1 ]
Kim, Hye Won [1 ]
Ahn, Hwa Young [1 ,2 ]
Yoon, Ji Won [1 ,2 ]
Kang, Seon Mee [1 ,2 ]
Park, Young Joo [1 ,2 ]
Jang, Hak Chul [1 ,2 ]
Lim, Soo [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, 300 Gumi Dong, Seongnam 463707, South Korea
来源
ANNALS OF GERIATRIC MEDICINE AND RESEARCH | 2010年 / 14卷 / 03期
关键词
Sarcopenia; Cardiometabolic risk factors; Elderly;
D O I
10.4235/jkgs.2010.14.3.121
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: The aim of this study was to investigate sarcopenia and its association with cardiometabolic risk factors in a community-based elderly cohort in Korea. Methods: We recruited 287 men and 278 women aged 65 years or older and without physical disability. Appendicular skeletal muscle mass (ASM) was measured with dual energy X-ray absorptiometry. We used two definitions for sarcopenia-ASM divided by height(2) (kg/m(2)) or by weight (%) <1 SD below the sex-specific mean for young adults. We compared RBP-4, adiponectin, hsCRP, lipid profiles, and insulin resistance between the sarcopenic and normal groups using ASM/Ht(2) and ASM/Wt. Results: The prevalence of sarcopenia was 35.3% in men and 13.4% in women with sarcopenia defined by ASM/Ht(2). However, it was 38.3% in men and 62.6% in women by ASM/Wt. In correlation analysis, body mass index was positively correlated with ASM/Ht(2) and negatively correlated with ASM/Wt. The sarcopenic group, when defined as ASM/Ht(2), showed lower RBP4, fasting plasma glucose, and HOMA-IR and higher adiponectin than the normal group but not significantly different lipid profiles. The sarcopenic group defined by ASM/Wt had higher RBP4, fasting plasma glucose, and HOMA-IR, and lower adiponectin than the normal group in both sexes. Only in the males did the sarcopenic group defined by ASM/Wt reveal higher total cholesterol, triglycerides, and LDL cholesterol, and lower HDL cholesterol than the normal group. Conclusion: In conclusion, the sarcopenic group defined by ASM/Wt was more closely associated with cardiometabolic risk factors than the normal group in a community-based elderly cohort.
引用
收藏
页码:121 / 130
页数:10
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