Modeling intratumor heterogeneity through CRISPR-barcodes

被引：6

作者：

Guernet, Alexis ^{[1
,2
]}

Aaronson, Stuart A. ^{[3
]}

Anouar, Youssef ^{[1
,2
]}

Grumolato, Luca ^{[1
,2
]}

机构：

[1] Normandie Univ, UNIROUEN, INSERM, DC2N, Rouen, France

[2] Inst Res & Innovat Biomed, Rouen, France

[3] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 06期

关键词：

ALK; APC; CRISPR/Cas9; EGFR; genetic barcoding; non-small cell lung cancer; resistance; TP53; tumor heterogeneity;

D O I：

10.1080/23723556.2016.1227894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.

引用

页数：3

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