Association of adiponectin gene polymorphism and its levels with Hepatitis B Virus related disease in the population of Assam, India

Despite the important role of adiponectin in the progression of pathogenesis of liver cirrhosis, few data have been collected from the patients with different stages of liver diseases related to hepatitis B virus infection. We have studied the role of adiponectin in hepatitis B patients. Experiments were conducted an OPD-based cross-sectional study in a tertiary care hospital Assam, India which is a HBV-endemic country. A total of 220HBV-infected individuals and 110 healthy controls, were assessed for serum adiponectin levels which were quantified by enzyme-linked immunosorbent assay. Serum HBV viral load and markers, serum alanine aminotransferase levels and metabolic factors and also the single nucleotide polymorphism of Adiponectin were analysed. Adiponectin levels were found to be associated with the chronic HBV infection (p<0.05). The presence of HBV infection was found to be positively associated with serum adiponectin levels(P < 0.0001). Out study has also reported that allele TG of SNPrs2241766 (p<0.05, OR= 2.03), GT of rs1501299(p<0.05, OR= 1.78) and CG of SNPrs266729 (p<0.05, OR= 2.11) has a significant effect on this disease. Study findings were also expressed that, the serum adiponectin levels were positively associated with HBV viral load in overweight to HBV-infected subjects (p<0.05). The quantitative value of adiponectin was found higher in those patients with viral load of about 200x103-200x106 log copies/ml. Although the chronic HBV-infected individuals were more severe than the healthy controls, they were found as significantly higher serum adiponectin levels than healthy persons. Also it was found that the adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects. It is now possible to suggest that serum adiponectin may have a role in the progression in fibrosis in CHB infection.