PERSISTENT ORAL DYSKINESIAS IN HALOPERIDOL-WITHDRAWN NEONATAL 6-HYDROXYDOPAMINE-LESIONED RATS

被引:0
|
作者
HUANG, NY [1 ]
KOSTRZEWA, RM [1 ]
机构
[1] E TENNESSEE STATE UNIV,QUILLEN DISHNER COLL MED,DEPT PHARMACOL,JOHNSON CITY,TN 37614
关键词
HALOPERIDOL; ORAL DYSKINESIA; 6-HYDROXYDOPAMINE; TARDIVE DYSKINESIA;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Because chronic haloperidol-treated rats demonstrate an increased incidence of spontaneous oral activity, while neonatal 6-hydroxydopamine-lesioned rats demonstrate an increased incidence of dopamine agonist-induced oral activity, we studied the influence of haloperidol in 6-hydroxydopamine-lesioned rats. At 3 days after birth rats received 6-hydroxydopamine hydrobromide (200 mu g intracerebroventricularly; desipramine pretreatment, 20 mg/kg i.p., 1 h) or vehicle. Two months later haloperidol (1.5 mg/kg per day X 2 days per week, for 4 weeks; then 1.5 mg/kg per day, every day for 10 months) was added to the drinking water. After 15 weeks the level of spontaneous oral activity was stable. At 11 months there were 35.8 +/- 4.9 vs. 18.4 +/- 2.1 oral movements in 6-hydroxydopamine-lesioned vs. intact rats receiving haloperidol. This effect persisted unabated in lesioned rats for 4 months after haloperidol withdrawal. This stable high frequency of oral dyskinesias is an advantage for studying putative therapeutic drugs for tardive dyskinesia.
引用
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页码:433 / 437
页数:5
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