The GEM Project: Stool metabolomic profile is associated with microbiome risk score and with future onset of Crohn's disease in healthy first-degree relatives

被引:0
|
作者
Lee, S. H. [1 ]
Garay, J. A. Raygoza [1 ]
Turpin, W. [1 ]
Smith, M. I. [1 ]
Goethel, A. [1 ]
Griffiths, A. [2 ]
Moayyedi, P. [3 ]
Espin-Garcia, O. [4 ]
Abreu, M. [5 ]
Aumais, G. [6 ]
Bernstein, C. N. [7 ]
Biron, I. [8 ]
Cino, M. [9 ]
Deslandres, C. [10 ]
Dotan, I. [8 ]
El-Matary, W.
Feagan, B. [11 ,12 ,13 ]
Guttman, D. [14 ]
Huynh, H. [15 ]
Hyams, J. [16 ]
Jacobson, K. [17 ]
Mack, D. [18 ,19 ]
Marshall, J.
Otley, A. [20 ]
Panaccione, R. [21 ]
Ropeleski, M. [22 ]
Silverberg, M. S. [1 ]
Steinhart, A. H. [1 ]
Turner, D. [23 ]
Yerushalmi, B. [24 ,25 ]
Xu, W. [4 ]
Croitoru, K. [1 ]
机构
[1] Univ Toronto, Mt Sinai Hosp, Div Gastroenterol, Toronto, ON, Canada
[2] Hosp Sick Children, Div Gastroenterol, Toronto, ON, Canada
[3] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Med, Hamilton, ON, Canada
[4] Univ Toronto, Div Biostat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[5] Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL USA
[6] Hop Maison Neuve Rosemont, Dept Gastroenterol, Montreal, PQ, Canada
[7] Univ Manitoba, Inflammatory Bowel Dis Clin & Res Ctr, Winnipeg, MB, Canada
[8] Univ Toronto, Div Gastroenterol & Hepatol, Toronto, ON, Canada
[9] CHU St Justine, Dept Gastroenterol, Montreal, PQ, Canada
[10] Univ Manitoba, Pediat Gastroenterol, Winnipeg, MB, Canada
[11] Univ Western Ontario, Dept Med, London, ON, Canada
[12] Univ Western Ontario, Dept Epidemiol, London, ON, Canada
[13] Univ Western Ontario, Dept Biostat, London, ON, Canada
[14] Univ Toronto, Ctr Anal Genome Evolut & Funct, Toronto, ON, Canada
[15] Univ Alberta, Dept Pediat, Edmonton, AB, Canada
[16] Connecticut Childrens Med Ctr, Div Digest Diseases Hepatol & Nutr, Hartford, CT USA
[17] British Columbia Childrens Hosp, Dept Pediat, Vancouver, BC, Canada
[18] Childrens Hosp Eastern Ontario, Ottawa, ON, Canada
[19] Univ Ottawa, Div Gastroenterol Hepatol & Nutr, Ottawa, ON, Canada
[20] Dalhousie Univ, Div Gastroenterol, Izaak Walton Killam Hosp, Halifax, NS, Canada
[21] Univ Calgary, Dept Gastroenterol, Calgary, AB, Canada
[22] Queens Univ, Gastrointestinal Dis Res Unit, Dept Med, Kingston, ON, Canada
[23] Hebrew Univ Jerusalem, Juliet Keidan Inst Pediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Jerusalem, Israel
[24] Soroka Univ, Med Ctr, Beer Sheva, Israel
[25] Ben Gurion Univ Negev, Fac Hlth Sci, Pediat Gastroenterol Unit, Beer Sheva, Israel
来源
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
P700
引用
收藏
页码:I596 / I597
页数:2
相关论文
共 50 条
  • [41] Risk of Parkinson's disease among first-degree relatives: A community-based study
    Marder, K
    Tang, MX
    Mejia, H
    Alfaro, B
    Cote, L
    Louis, E
    Groves, J
    Mayeux, R
    NEUROLOGY, 1996, 47 (01) : 155 - 160
  • [42] Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: The REVEAL study
    Cupples, LA
    Farrer, LA
    Sadovnick, AD
    Relkin, N
    Whitehouse, P
    Green, RC
    GENETICS IN MEDICINE, 2004, 6 (04) : 192 - 196
  • [43] Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease
    Indaram AVK
    Nandi S
    Weissman S
    Lam S
    Bailey B
    Blumstein M
    Greenberg R
    Bank S
    World Journal of Gastroenterology, 2000, 6 (01) : 49 - 52
  • [44] Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease
    Indaram, AVK
    Nandi, S
    Weissman, S
    Lam, S
    Bailey, B
    Blumstein, M
    Greenberg, R
    Bank, S
    WORLD JOURNAL OF GASTROENTEROLOGY, 2000, 6 (01) : 49 - 52
  • [45] High Serum Aβ and Vascular Risk Factors in First-Degree Relatives of Alzheimer’s Disease Patients
    Laila Abdullah
    Cheryl Luis
    Daniel Paris
    Ghania Ait-ghezala
    Benoit Mouzon
    Elizabeth Allen
    Julia Parrish
    Myles A. Mullan
    Scott Ferguson
    Marcie Wood
    Fiona Crawford
    Michael Mullan
    Molecular Medicine, 2009, 15 : 95 - 100
  • [46] High Serum Aβ and Vascular Risk Factors in First-Degree Relatives of Alzheimer's Disease Patients
    Abdullah, Laila
    Luis, Cheryl
    Paris, Daniel
    Ait-ghezala, Ghania
    Mouzon, Benoit
    Allen, Elizabeth
    Parrish, Julia
    Mullan, Myles A.
    Ferguson, Scott
    Wood, Marcie
    Crawford, Fiona
    Mullan, Michael
    MOLECULAR MEDICINE, 2009, 15 (3-4) : 95 - 100
  • [47] Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease
    Fichna, Marta
    Malecki, Piotr P.
    Mlodzikowska, Mirela
    Gebarski, Boleslaw
    Ruchala, Marek
    Fichna, Piotr
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2020, 183 (01) : 73 - 81
  • [48] The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's Disease
    Kevans, David
    Madsen, Karen
    Silverberg, Mark S.
    Xu, Wei
    Shestopaloff, Konstantin
    Onay, Ummiye Venus
    Paterson, Andrew D.
    Griffiths, Anne M.
    Moayyedi, Paul
    Ropeleski, Mark J.
    Beck, Paul L.
    Bernstein, Charles N.
    Bitton, Alain
    Dieleman, Levinus A.
    Guttman, David S.
    Huynh, Hien Q.
    Jacobson, Kevan
    Kaplan, Gilaad G.
    Marshall, John K.
    Panaccione, Remo
    Seidman, Ernest G.
    Siminovitch, Kathy
    Snider, Denis
    Stadnyk, Andrew
    Steinhart, A. Hillary
    Surette, Michael
    Turner, Dan
    Vallance, Bruce
    Walters, Thomas D.
    Croitoru, Ken
    GASTROENTEROLOGY, 2013, 144 (05) : S835 - S835
  • [49] Evaluation of Genetic and Microbial Determinants of Intestinal Permeability in Healthy First Degree Relatives of Crohn's Disease
    Kevans, David
    Turpin, Williams
    Madsen, Karen
    Meddings, Jon
    Moreno-Hagelsieb, Gabriel
    Xu, Wei
    Silverberg, Mark S.
    Paterson, Andrew D.
    Croitoru, Ken
    GASTROENTEROLOGY, 2014, 146 (05) : S36 - S36
  • [50] STOOL FROM HEALTHY FIRST DEGREE RELATIVES OF CROHN'S DISEASE PATIENTS WHO LATER DEVELOP CROHN'S DISEASE ALTERS FECAL METABOLITES AND PROMOTES INFLAMMATION IN GERM-FREE MICE
    Dang, Cong Phi
    Xue, Mingyue
    Chen-Liaw, Alice
    Luchak, Alexander
    Lee, Sun-Ho
    Mogno, Ilaria
    Moayyedi, Paul
    Griffiths, Anne M.
    Deslandres, Colette
    Murthy, Sanjay K.
    Steinhart, A. Hillary
    Otley, Anthony
    Dieleman, Levinus A.
    Jacobson, Kevan
    Rubin, David T.
    Panaccione, Remo
    Feagan, Brian G.
    Streutker, Catherine
    Britton, Graham J.
    Faith, Jeremiah
    Turpin, Williams
    Croitoru, Kenneth
    GASTROENTEROLOGY, 2024, 166 (05) : S550 - S550